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Closed-Loop Modulation of a Notch-Filter Stimulation Strategy for Tremor Management with a Neuroprosthesis

机译:陷波滤波器刺激策略与神经假体的震颤处理的闭环调制。

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摘要

Tremor is the most common movement disorder, and one of the major causes of functional disability. In spite of the existence of various treatments, tremor is not managed effectively in a large number of patients, which make it a major cause of loss of quality of life. Here we present a novel strategy for tremor suppression through neurostimulation that replicates an adaptive notch-filter at the frequency of the tremor. The controller, which adapts the neurostimulation to the ongoing amplitude, frequency and phase of the tremor, is implemented in a wearable neuroprosthesis for tremor management. Experimental results in one patient with severe essential tremor illustrate the interest of the approach.
机译:震颤是最常见的运动障碍,也是功能障碍的主要原因之一。尽管存在各种治疗方法,但仍有大量患者不能有效地控制震颤,这使其成为生活质量下降的主要原因。在这里,我们提出了一种通过神经刺激抑制震颤的新策略,该策略在震颤的频率上复制了一个自适应陷波滤波器。该控制器使神经刺激适应于震颤的持续幅度,频率和相位,并在可穿戴的神经假体中实现震颤处理。一名患有严重原发性震颤的患者的实验结果表明了该方法的重要性。

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